|
Symbol Name ID |
Tcf4
transcription factor 4 MGI:98506 |
| Darker colors indicate more annotations |
| Human Phenotypes | Microcephaly |
Secondary microcephaly |
Aganglionic megacolon |
Pituitary adenoma |
Glioblastoma multiforme |
Ventriculomegaly |
Small cerebral cortex |
Aplasia/Hypoplasia of the corpus callosum |
Hypoplasia of the corpus callosum |
Hypoplastic hippocampus |
Benign neoplasm of the central nervous system |
Neuroblastoma |
Ataxia |
Gait ataxia |
Incoordination |
Abnormal pyramidal sign |
Hemiplegia/hemiparesis |
Increased intracranial pressure |
Echolalia |
Abnormality of speech or vocalization |
Absent speech |
Aphasia |
Dysarthria |
Dysgraphia |
Mutism |
Depression |
Irritability |
Disturbed sensory perception |
Anxiety |
Hallucinations |
Atypical behavior |
Happy demeanor |
Autistic behavior |
Aggressive behavior |
Attention deficit hyperactivity disorder |
Motor stereotypy |
Self-injurious behavior |
Memory impairment |
Intellectual disability |
Intellectual disability, moderate |
Intellectual disability, progressive |
Intellectual disability, severe |
Sleep abnormality |
Sleep apnea |
Dyskinesia |
Gait disturbance |
Migraine |
Developmental regression |
Global developmental delay |
Motor delay |
Specific learning disability |
Seizure |
Paresthesia |
| Disease(s) Associated with TCF4 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lynch syndrome | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pitt-Hopkins syndrome |
| Mouse Phenotypes | abnormal brain morphology |
abnormal brain development |
decreased brain weight |
abnormal corpus callosum morphology |
abnormal dentate gyrus morphology |
decreased hippocampus volume |
thin cerebral cortex |
abnormal action potential |
reduced sensorimotor gating |
enhanced NMDA-mediated synaptic currents |
enhanced long-term potentiation |
abnormal prepulse inhibition |
decreased prepulse inhibition |
increased prepulse inhibition |
|
| Availability | Mouse Genotype | ||||||||||||||
| Tcf4tm1Zhu/Tcf4tm1Zhu | |||||||||||||||
| Tcf4tm1a(EUCOMM)Wtsi/Tcf4+ | |||||||||||||||
| Tcf4tm1Zhu/Tcf4+ | |||||||||||||||
| Tg(Thy1-Tcf4)1Mjro/0 | |||||||||||||||
| Tcf4em1Bdph/? | |||||||||||||||
| Tcf4em2Bdph/? | |||||||||||||||
| Tcf4tm1Hmb/Tcf4+ Tmem163Tg(ACTB-cre)2Mrt/Tmem163+ (conditional) |
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| Tcf4tm1Hmb/Tcf4+ Tg(Nes-cre)1Kln/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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